Mark Basik was born in Montreal and studied medicine at McGill University. He then went on to complete a general surgical residency at Université de Montréal, followed by a fellowship in surgical oncology at Roswell Park Cancer Institute, in Buffalo, New York. After working as a surgical oncologist at Hôtel-Dieu Hospital in Montreal, he returned to the United States as a visiting investigator at the National Human Genome Research Institute in Maryland and then came back to Canada to continue practising medicine.
Why Choosing Breast Cancer?
As a surgical resident, I was fascinated by clinical research protocols in the field of breast cancer. Now that I am a breast cancer surgeon, the relationship with my patients motivates me to find a cure to breast cancer.
A Scientific Accomplishment You Are Proud of
The discovery of two tumour-suppressor genes, ARID1A and SPEN, in hormone-dependent breast cancers. Mutations of these two genes are present in a small number of patients with breast cancer, which could affect their response to hormonal treatments, such as tamoxifen.
- The biology of cancer
- Cancer treatment
- The development of scientific models
Projects Funded by the Foundation
2004 – Discovery of novel tumour-suppressor genes in breast cancer
2008 – The role of DARPP-32 in resistance to trastuzumab in breast cancer
2012 – The role of ARID1A in estrogen-receptor-positive breast cancer
2012 – Molecular profiling of drug-resistant triple negative breast cancer
2013 – A novel tumour-suppressor gene in estrogen-receptor-positive breast cancer
2014 – New generation diagnostics in breast cancer
2015 – Dissecting the tumour-suppressive functions of SPEN in ER+ breast cancers