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Mark Basik

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Mark Basik
Mark Basik Clinician Researcher, Jewish General Hospital / Associate Professor and Researcher Department of Oncology, Faculty of Medicine, McGill University, Montreal

Bio

Mark Basik was born in Montreal and studied medicine at McGill University. He then went on to complete a general surgical residency at Université de Montréal, followed by a fellowship in surgical oncology at Roswell Park Cancer Institute, in Buffalo, New York. After working as a surgical oncologist at Hôtel-Dieu Hospital in Montreal, he returned to the United States as a visiting investigator at the National Human Genome Research Institute in Maryland and then came back to Canada to continue practising medicine.

Why Choosing Breast Cancer?

As a surgical resident, I was fascinated by clinical research protocols in the field of breast cancer. Now that I am a breast cancer surgeon, the relationship with my patients motivates me to find a cure to breast cancer.    

A Scientific Accomplishment You Are Proud of

The discovery of two tumour-suppressor genes, ARID1A and SPEN, in hormone-dependent breast cancers. Mutations of these two genes are present in a small number of patients with breast cancer, which could affect their response to hormonal treatments, such as tamoxifen.

Research Focus

  • The biology of cancer
  • Cancer treatment
  • The development of scientific models

Projects Funded by the Foundation

2004 – Discovery of novel tumour-suppressor genes in breast cancer

2008 – The role of DARPP-32 in resistance to trastuzumab in breast cancer

2012 – The role of ARID1A in estrogen-receptor-positive breast cancer

2012 – Molecular profiling of drug-resistant triple negative breast cancer

2013 – A novel tumour-suppressor gene in estrogen-receptor-positive breast cancer

2014 – New generation diagnostics in breast cancer     

2015 – Dissecting the tumour-suppressive functions of SPEN in ER+ breast cancers