Jean-François Côté completed a doctorate under the supervision of Michel Tremblay of McGill University’s Department of Biochemistry where he studied the signalling pathways that control cell migration. He then joined the laboratory of Kristiina Vuori (president of the Sanford Burnham Prebys Medical Discovery Institute) for four years, during which time he identified new proteins and molecular mechanisms leading to the motile behaviour of aggressive cancer cells. Recruited by the IRCM in 2005, he currently leads a research program focused on understanding the molecular mechanisms that lead to metastasis formation.
Why Choosing Breast Cancer?
Metastasis formation remains a major challenge in the treatment of breast cancer. The objective of our team is to identify the signalling pathways that control the spreading of cancer cells in order to develop new therapies that will prevent or eliminate the formation of cancer cells.
A Scientific Accomplishment You Are Proud of
Our laboratory has identified the DOCK1 protein complex as a molecular target for the development of new drugs that will inhibit the progression of cancer cells.
Field(s) of Research
- Biology of cancer
- Molecular signalling controlling metastasis formation
2013-2017 – Senior Research Scholar, Fonds de recherche du Québec – Santé (FRQS)
2014 – Marcel-Piché Prize
2013 –Pierre Bois Fund for Excellence, Institut de recherches cliniques de Montréal (IRCM)
2013 –Top 10 Reseach Impact Stories, Canadian Cancer Society
Projects Funded by the Foundation
2011 – Mechanism of breast cancer metastasis: AXL signalling in the tumour microenvironment