- Canada Research Chair in Chromatin Biology and Molecular Epigenetics
- Researcher, St-Patrick Research Group in Basic Oncology, Cancer Research Centre, Université Laval, Oncology Division, CHU de Québec Research Centre-Université Laval
Jacques Côté completed a doctorate in molecular and cellular biology at Université Laval, as well as a post-doctorate in molecular biology and biochemistry at Pennsylvania State University.
His team’s activities are focused on understanding the epigenetic mechanisms that control the genome expression and stability. These mechanisms are at the heart of the phenomenon whereby cells from different tissues in the human body can have their own individual roles and characteristics while having the same genetic material. For the same reason, actors in these mechanisms are involved in all forms of cancers and other diseases.
Why Choosing Breast Cancer?
What interests him the most are the predominant aspect of this type of cancer and its impact on the women in Quebec, understanding its genetic and hormonal bases, and the actual short term potential for developing new, better targeted diagnostic and therapeutic approaches.
A Scientific Accomplishment You Are Proud of
Discoveries made in my lab have, for the first time, demonstrated the critical role of factors changing epigenetic marks in the process of repair and replication of the genome. These works are directly related to the function of several oncogenes and tumour suppressors.
Field(s) of Research
- Cancer biology
- Etiology (causes)
- Screening, diagnosis or prognosis
- Development of scientific models
2014-2017 – Member of the Medical Review Panel for the Canada Gairdner International Awards
2008-2022 – Canada Research Chair
2006 – Prix du jeune chercheur André-Dupont, Club de recherche clinique du Québec/FRQS
2005 – Article “Cote et al., Science, 1994” identified by Nature, in 2005, as one of the 23 milestones in transcription during the last 50 years
1998-2008 – Fellow researcher of the CIHR
1993 – Article “Cote et al., Science, 1993” named one of the top 10 discoveries of the year 1993 in Quebec, according to the Québec Science magazine
Projects Funded by the Foundation
2014 – Acetylation of Breast Cancer Suppressors BRCA1, BRCA2 and PALB2: Functional Links to an Anticancer Approach